Selected publications (For the complete list of publications click here)

Hartman, T., Weinrick, B.,  Vilcheze, C., Berney, M., Tufariello, J.M., G. M. Cook., and W. R. Jacobs, Jr. (2014) Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. PloS Pathogens. 10(11):e1004510. PMCID PMC 4161257.

Vilchèze, C., Hartman, T., Weinrick, B., and Jacobs, W.R. (2013). Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction. Nat. Commun 4:1881. PMCID PMC  3698613.

Goldberg, D.E., Siliciano,R.F., and Jacobs, W.R. Jr. (2012). Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV. Cell 148:1271-83. PMCID PMC 3322542.

Jain, P., Hartman, T.,  Eisenberg, N., O’Donnell, M.R., Kriakov, J.,  Govender, K.,  Makume, M., Thaler, D., Hatfull, G.F., Sturm, A.W.,  Larsen, M.H., Moodley, P., Jacobs,W.R. Jr. (2012) ф2GFP10: A high-intensity fluorophage enables detection and rapid drug susceptibility testing of Mycobacterium tuberculosis directly from sputum samples. J Clin Microbiol 50:1362-9. PMCID PMC 3318544.

Sweeney, K. A., D. N. Dao, M. F. Goldberg, T. Hsu, M. M. Venkataswamy, M. Henao-Tamayo, D. Ordway, R. S. Sellers, P. Jain, B. Chen, M. Chen, J. Kim, R. Lukose, J. Chan, I. M. Orme, S. A. Porcelli, and W. R. Jacobs, Jr. (2011). A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med 17:1261-8. PMCID PMC 3250071.

Jain, P., D. S. Thaler, M. Maiga, G. S. Timmins, W. R. Bishai, G. F. Hatfull, M. H. Larsen, and W. R. Jacobs. (2011). Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy. J Infect Dis 204 Suppl 4:S1142-50. PMCID PMC 3247800.

Kalscheuer, R., Syson, K., Veeraraghavan, U., Weinrick, B., Biermann, K.E., Liu, Z., Sacchettini, J.C., Besra, G., Bornemann, S., Jacobs, W.R., Jr. (2010) Self-poisoning of Mycobacterium tuberculosis by inhibition of GlgE reveals a new class of drug target. Nature Chem Bio. 6(5):376-84. PMCID PMC3256575.

Kalscheuer, R., B. Weinrick, U. Veeraraghavan, G. S. Besra, and W. R. Jacobs, Jr. (2010). Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A.PMCID PMC3003129.

Vilchèze C and Jacobs WR Jr. The Mechanism of Isoniazid Killing: Clarity Through the Scope of Genetics. Annu. Rev. Microbiol., 2007, 61:35-50.

Cox, J.S., Chen, B., McNeil, M. and Jacobs, W.R., Jr.  (1999) Complex Lipid Determines Tissue-Specific Replication of Mycobacterium tuberculosis in Mice. Nature 402:79-83.



Selected publications (For the complete list of publications click here)

Kozakiewicz L, Chen Y, Xu J, Wang Y, Dunussi-Joannopoulos K, Ou Q, Flynn JL, Porcelli SA, Jacobs WR, Jr., Chan J. 2013. B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. PLoS Pathog 9: e1003472

Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, Basaraba R, So M, Zhu G, Tufariello JM, Izzo AA, Orme IM, Almo SC, Leyh TS, Chan J. 2009. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection. PLoS Pathog 5:e1000460

Russell-Goldman E, Xu J, Wang X, Chan J., Tufariello JM. 2008. A double Rpf knockout Mycobacterium tuberculosis strain exhibits profound defects in reactivation from chronic tuberculosis and innate immunity phenotypes. Infect Immun. 76:4269-81.

Maglione PJ, Xu J, Casadevall A, Chan J. 2008. Fcgamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis Infection. J Immunol 180:3329-38.

Chakravarty SD, Zhu G, Tsai MC, Mohan VP, Marino S, Kirschner DE, Huang L, Flynn J, Chan J. 2008. Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. Infect Immun. 76:916-26.

Maglione PJ, Xu J, Chan J. 2007. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol 178:7222-34.

Chakravarty SD, Xu J, Lu B, Gerard C, Flynn J, Chan J. 2007. The chemokine receptor CXCR3 attenuates the control of chronic Mycobacterium tuberculosis infection in BALB/c mice. J Immunol 178:1723-35.

Tufariello JM, Mi K, Xu J, Manabe YC, Kesavan AK, Drumm J, Tanaka K, Jacobs WR, Jr., Chan J. 2006. Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis. Infect Immun 74: 2985-95

Selected publications (For the complete list of publications click here)

Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreno LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40: 105-16

Venkataswamy MM, Goldberg MF, Baena A, Chan J, Jacobs WR Jr and Porcelli SA. In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG. Vaccine. 30:1038-49 (2012).

Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA and Jacobs WR Jr.  A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.  Nature Medicine 17:1261-8 (2011).

Arora P, Venkataswamy MM, Baena A, Bricard G, Li Q, Veerapen N, Ndonye R, Park JJ, Lee JH, Seo KC, Howell AR, Chang YT, Illarionov PA, Besra GS, Chung SK and Porcelli SA.  A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids. J Am Chem Soc. 133:5198-201 (2011).

Im JS, Arora P, Bricard G, Molano A, Venkataswamy MM, Baine I, Jerud ES, Goldberg MF, Yu KOA, Ndonye RM, Howell AR, Yuan W, Cresswell P, Chang YT, Illarionov PA, Besra GS and Porcelli SA. Kinetics and cellular site of glycolipid loading control the outcome of Natural Killer T cell activation. Immunity 30:888-98 (2009).

Venkataswamy MM, Baena A, Goldberg M, Bricard G, Im JS, Besra GS, Chan J, Jacobs Jr. WR and Porcelli SA. Enhancement of immunogenicity of M. bovis BCG by incorporation of NKT cell activating glycolipids. J Immunol. 183:1644-56 (2009).

Baena A, Porcelli SA. Evasion and subversion of antigen presentation by Mycobacterium tuberculosis. Tissue Antigens 74:189-204 (2009).

Porcelli, SA. Tuberculosis: Shrewd survival strategy. Nature 454:702-3 (2008).

Porcelli SA and Jacobs, WR Jr. Tuberculosis: unsealing the apoptotic envelope (News & Views). Nature Immunol. 9:1101-2 (2008).

Hinchey J, Lee S, Manjunatha V, Chen B, Basaraba RJ, Jeon BY, Derrick SC, Chan J, Braunstein M, Orme IM, Morris, SL, Jacobs Jr. WR, Morris SL, Porcelli SA. Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. J. Clin. Invest. 117:2279-2288 (2007).

For the complete list of publications click here

For the complete list of publications click here

For the complete list of publications click here